بررسی سطح سرمی hsCRP با شدت درگیری عروق کرونر

Abstract Background: Coronary artery disease, (CAD) is an important risk for morbidity and mortality. Because of controversial reports about relation between high-sensitivity C-reactive protein (hs-CRP) level and the severity of coronary artery stenosis, this study was done in Taleghani Hospital. Methods: In this case-control study 85 patients with CAD undergoing coronary angiography were studied. Angiography findings were based on severity of disease according to the Gensini score: 50 as severe. Blood samples (1mL) were collected from each patient. After centrifugation in laboratory the level of hs-CRP were measured, and classified in three levels: 3mg/L respectively as mild, moderate and significant elevation of hs-CRP. Correlation of these levels with the severity of CAD was analyzed with chi-square test. Result: Out of 85 subjects, 64.7% were males mean age 55.7±7.06 years. In 28.2% the hs-CRP level were 3mg/L. Findings revealed significant elevation of hs-CRP level in patients with moderate and severe coronary artery stenosis (p<0.01). Conclusion: Findings of this study demonstrated correlation between serum hs-CRP level and severity of coronary artery stenosis. Keywords: Gensini score, Severity of coronary stenosis, hs-CRP